Common side effects may include:

Hematologic: Lymphopenia, thrombocytopenia, anemia, neutropenia

Gastrointestinal: Diarrhea, nausea, decreased appetite, constipation, stomatitis

Dermatologic: Rash, dry skin, nail toxicity, pruritus

-Rash cases included various types of rash (generalized, erythematous, macular, maculo-papular, papular, pustular), erythema, folliculitis, acne, dermatitis, and acneform dermatitis

-Dry skin included eczema, skin fissures, and xerosis

-Nail toxicity included nail and nail bed disorders, nail bed inflammation, nail bed tenderness, nail discoloration, nail dystrophy, nail infection, nail ridging, onychoclasis, onycholysis, onychomadesis, and paronychia

Metabolic: Hyponatremia, hypermagnesemia

Ocular: Eye disorders included dry eye, blurred vision, keratitis, cataract, eye irritation, blepharitis, eye pain, increased lacrimation, and vitreous floaters

Respiratory: Cough

Musculoskeletal: Back pain

Nervous system: Headache

Cardiovascular: Cardiomyopathy

Other: Venous thromboembolism included cases of deep vein thrombosis, jugular venous thrombosis, and pulmonary embolism

Call your doctor at once if you have:

• shortness of breath even with mild exertion;
• fast or pounding heartbeats;
• a light-headed feeling, like you might pass out;
• swelling, rapid weight gain; or
• new or worsening lung symptoms–sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath.